Humanness (HScore)

How human is your antibody?

17.03.06 Warning

Unfortunately there were some errors in the calculations of Z-scores, in particular for the comparison with the light chain set (i.e. lambda and kappa together). Comparative results between antibodies were valid but the absolute values were incorrect. This has now been revised.

This page enables you to match your antibody sequence against a database of characterized Human and Murine Antibody sequences.

Please enter the Light Chain or Heavy Chain Amino Acid sequence (single letter) of your Antibody

Please select the database against which you wish to query the sequence

Human light chain sequences
Human heavy chain sequences
Human Lambda class sequences
Human Kappa class sequences
Show the Mouse Z-scores distribution

For more information and if you publish results based on this server, please see or cite Abhinandan, K. R. and Martin, Andrew C. R. (2007) Analyzing the 'degree of humanness' of antibody sequences, J. Mol. Biol, 369, 852-862. DOI: 10.1016/j.jmb.2007.02.100

Commercial Use

Companies may use this public server, but need to be aware that data are not encrypted and it is not secure.

After trialing the system, companies should consider abYsis. A commercial licence will enable you to install a local version of this code together with an integrated database which can also store and analyse proprietary sequence and structure data.

For information on commercial licences, please contact the distributor Ebisu.