Humanness (GScore)

GScore - Germinality Index Calculator

Calculate the geminality humanness score of a given amino acid sequence relative to the germ-line variables genes from the NCBI databases.

The method is described in: Thullier, Huish, Pelat and Martin (2010) The humanness of macaque antibody sequences J. Mol. Biol. 396:1439-1450. [doi:10.1016/j.jmb.2009.12.041]

If you get any error or warning messages, please check you have entered your sequence correctly. Strange sequence features may cause the similarity search stage to fail. Long input sequences are truncated at 500 amino acids. .

Enter the amino acid sequence of your antibody variable region:


REST Access

You may access the GScore server directly from your scripts using a URI of the form:

Columns in the CSV output are:

  • Germline ID
  • G-Score
  • Mean of Means (Raw humanness)
  • Standard Deviation
  • Germline Count

Copyright (c) 2009-2022, Oliver Huish and Andrew C.R. Martin, UCL